Each technology will get one industrial revolution. Ours is AI – nonetheless novel, not but totally understood, however sure to turn out to be so embedded in life that we’ll neglect how we ever labored with out it. The query isn’t if AI will remodel the world, however who could be relied upon to revenue from it all through the 25-year arc forward of us. My wager is Microsoft (Nasdaq: MSFT). Now 50 years previous, Microsoft has turned repeated reinvention into an artwork. Home windows within the Nineteen Eighties, Workplace within the Nineteen Nineties, the cloud within the 2010s, and now AI integration. It’s the similar playbook: construct important instruments, make them indispensable, then cost hire for his or her use. This quiet consistency has made it the default working system of recent enterprise.
Microsoft is the spine of labor. Home windows powers round 70% of desktop PCs, Workplace 365 counts greater than 400 million paid industrial prospects, and Azure holds roughly 23% of the worldwide cloud market, relying on who you ask. Final yr’s income topped $240 billion. The stability sheet carries additional cash than some international locations, the dividend has risen yearly since 2003, and buybacks proceed by the tens of billions.
AI is just the subsequent wave. Via its multibillion-dollar partnership with OpenAI, Microsoft is now constructing “Copilot” intelligence into Phrase, Excel, Outlook and Groups, software program utilized by a couple of billion folks. It earns each from the infrastructure that powers AI and from the purposes that use it.
The bears will say the inventory is priced for perfection, and it’s actually true that Microsoft’s shares aren’t low-cost. However high quality not often is. Its sturdiness, recurring income and international model kind a aggressive benefit few can match. Microsoft isn’t the story of each new know-how; it’s the story of creating know-how pay. Hype doesn’t compound. Gross sales and earnings do. If AI defines the subsequent quarter-century, Microsoft is the way you play it.

Photo voltaic panels don’t final endlessly, and the world has an enormous downside on its fingers: eight million tonnes of photo voltaic panel waste by 2030, escalating to 80 million tonnes by 2050. Within the US greater than 90% of them find yourself as landfill, however they comprise poisonous heavy metals (together with lead, cadmium and selenium) that leach into soil and groundwater, posing dangers to ecosystems and human well being. California has already banned them from landfills.
Panels are designed for sturdiness. This very trait, by no means thoughts their advanced composition, makes recycling tough. The US may have a million tonnes needing recycling by 2030, most of them within the south-western states. Comstock (NYSE: LODE) has fairly the first-mover benefit: a confirmed, functioning demonstration recycling facility in Nevada, which processes 135,000 panels a yr. It’s now establishing three extra full-scale services, the primary of which can be operational subsequent yr. Every lies simply throughout the border from California.
Comstock is paid a “dumping price” of $500 per tonne to take the panels (it prices the identical to ship them to landfill). It then recycles them, which prices $100 per tonne, to supply floor aluminium, floor glass, silver and copper, which it then sells for $200/ tonne. So for each tonne it processes, it makes $600, an 85% margin.
If the plan for 3 crops to be operational by 2030 (processing 300,000 tonnes) is profitable, that suggests $180 million in earnings, together with ten million ounces of silver manufacturing, which equates to a $1.8 billion valuation by 2030.
This firm has $100 million in actual property and silver mining properties value maybe $50 million. Plus a lottery ticket – 80% possession of a burgeoning biofuels enterprise valued at $1 billion. All this for a market cap of $150 million. Discuss an uneven alternative. The primary doubts encompass administration and their potential to execute. That’s what’s holding the share worth again.

Whereas everybody chases the subsequent AI unicorn, I desire to take a look at conventional sectors that would profit from this wave of know-how – agriculture and the meals trade, for instance. It faces main challenges: local weather change, growing regulation of environmental and social governance (ESG) and rising populations. International agriculture manufacturing might want to improve by 60%-70% by 2050, based on US agricultural equipment large Deere & Co. But useful resource shortage and local weather change make that tougher.
In the meantime, France and the eurozone look prone to face renewed financial and political turmoil, and the single-currency space may even fracture. Agriculture and commodities supply a hedge as tangible belongings. France, the previous breadbasket of Europe, is now a web importer of meals. Know-how is already serving to the sector in Europe. Robotic milking machines have turn out to be widespread over the previous 15 years. Satellite tv for pc-guided tractors permit farmers to handle a whole bunch of hectares single-handedly whereas monitoring soil well being and productiveness. These machines require common upkeep and substitute as a consequence of grime and mud, producing regular earnings streams.
I like to recommend the International X AgTech & Meals Innovation Ucits ETF (LSE: KROG) to revenue from this theme. The exchange-traded fund holds Deere and different corporations that may energy the farming revolution. I’d additionally think about investing in Corteva (NYSE: CTVA), a producer of seeds, and Trimble (Nasdaq: TRMB), which focuses on sensors. In 2050, I’ll hopefully be retiring to my farm in Brittany with a couple of golden Napoleons within the pocket, I’ll open the bottle of Armagnac I acquired from my first job at JPMorgan in Paris. I’ll then re-read this web page, actually with a smile.

Regardless that the defence trade depends closely on authorities spending, which could be cyclical and topic to the whims of politics, because of the character of the trade, contracts are sometimes very long-term. This implies the sector is engaging from an funding perspective, particularly as spending on defence is steadily growing around the globe.
Traders want solely take a look at Babcock, which has a hand in sustaining the UK’s nuclear deterrent, amongst different issues, to know simply how long-term this trade actually is. Within the firm’s 2024 annual outcomes presentation, it outlined the highway map for the UK’s present submarine fleet to 2080. This included the arrival of the UK’s new assault submarine class, deterrent submarine class and the disposal of fifty defunct vessels.
BAE provides one other instance of the chance within the sector. At its half-year outcomes, it reported an order backlog of £75 billion, three years’ income, with an additional £180 billion of potential within the pipeline. Which means the corporate can lock in round a decade of gross sales.
BAE is likely one of the giants of the sector within the UK, and each nation around the globe has their house defence champion. As such, one of the best ways to put money into the expansion of the defence trade worldwide is thru a broad-based ETF or defence-sector tracker fund. The iShares Europe Defence Ucits ETF (LSE: DFEU) holds probably the most outstanding European names within the sector, together with Germany’s Rheinmetall and France’s Thales, in addition to BAE and Rolls-Royce.
The iShares International Aerospace & Defence ETF (LSE: DFND) has a broader mandate and contains high holdings similar to GE Aerospace, Boeing and RTX, that are energetic within the defence market but additionally have civil arms. Lastly, there’s the Way forward for Defence Ucits ETF (LSE: NATP). This ETF blends tech and defence, with names like Palantir, Palo Alto and CrowdStrike within the high ten, in addition to the likes of BAE and Safran.

For those who had predicted in early 2000 that the know-how sector could be the best-performing space of the market over the subsequent 25 years, you’d have appeared like an fool after three after which been forgotten. No person would now keep in mind your prediction. However since know-how drives all financial progress, it’s a very good wager that it’ll once more lead the funding area over the subsequent 25 years, particularly since markets aren’t at a speculative peak as in 2000.
Volatility, common sharp setbacks and bear markets are inevitable however buyers who see these as shopping for alternatives and don’t panic are prone to do effectively. The apparent autos are the Polar Capital Know-how Belief (LSE: PCT) and Allianz Know-how Belief (LSE: ATT) however HgCapital Belief (LSE: HGT) and the tech-orientated Baillie Gifford trusts, Scottish Mortgage Funding Belief (LSE: SMT) and the Edinburgh Worldwide Funding Belief (LSE: EWI) also needs to do very effectively. AI is prone to be previous hat lengthy earlier than the 25 years are up, however different applied sciences will take over.
Quantum computing continues to be effectively wanting industrial utility, however could possibly be the subsequent revolutionary innovation. The unquoted PsiQuantum is a pacesetter within the area and one of many largest holdings of Edinburgh Worldwide. Enhancements in battery know-how have the potential to revolutionise transport and resolve the intermittency of renewable vitality and the unresponsiveness to demand of nuclear. Tesla appears the corporate almost definitely to succeed. Excessive publicity to innovation makes the US nonetheless the very best place to take a position.

There’s at present widespread and, for my part, well-placed concern that the AI shares dominating the market are hyped. The hazard of this narrative is that semiconductors – a phrase which I’ll comply with kind in utilizing pretty generically right here to check with the provision chain producing numerous sorts of laptop chip – have turn out to be synonymous with the know-how, and consequently danger being caught up within the unfolding AI narrative, for higher or worse.
Taking a short-term view, there isn’t a doubt that the valuations of many main semiconductor shares look stretched because of the AI hype. Broadcom has reached almost 87 occasions trailing earnings, whereas Superior Micro Units trades at over 100 on the identical metric after a surge of 40% following the announcement of an settlement with OpenAI. These numbers make Nvidia, the world’s first $5 trillion firm, look affordable on a piffling 54 occasions earnings.
However with a 25-year time horizon, the semiconductor trade seems to be an apparent play. It’s cyclical, and buyers ought to anticipate ups and downs, however whereas many semiconductor shares are at present overpriced because of AI, it’s a secure wager that the majority are at present undervalued in contrast with no matter comes alongside subsequent. Whether or not that’s quantum computing or robotics lastly gaining mainstream adoption, or one thing else that we will’t but think about, it’s an inexpensive assumption that semiconductor know-how will underpin the subsequent world-changing know-how.
The one actual danger to this speculation that I can see is that some know-how comes alongside that displaces semiconductors and laptop chips as we all know them. That might be a monumental financial and technological shift if it had been to occur. My assumption if it did is that it might both come from one of many present gamers or, if not, that one among these would purchase whichever start-up had found the know-how in a short time (Nvidia being the almost definitely in each cases given the assets it has accessible).
For now, observe that many corporations aren’t in truth overvalued. Taiwan Semiconductor trades at under 32 occasions earnings regardless of having a close to monopoly on superior chipmaking. ASML, one among Taiwan Semi’s suppliers with a close to monopoly on lithography, trades within the mid-thirties. Go energetic in case you like, however I’d go for a broad-based tracker to maximise the possibilities of capturing any future improvements within the sector. TSMC and ASML are the highest two holdings within the VanEck Semiconductor Ucits ETF (LSE: SMGB) and the First Belief Bloomberg International Semiconductor Provide Chain Ucits ETF (LON: FCHP).

Wanting again is simple, however as buyers we glance forward. It’s unlikely that the very best reply is within the rear-view mirror. Consistent with MoneyWeek’s tried and examined worth bias, it might be remiss of me to not current a contrarian worth commerce. Lengthy-term anticipated returns, estimated by the likes of funding administration group GMO, are destructive for US equities and modest for different main markets.
Clearly, they favour deep worth, however who doesn’t? One space that has upset is bonds. All of us appear to hate them, which implies the contrarians ought to examine. I favour index-linked bonds (linkers) as a result of they assure a optimistic actual return, which at present means no matter inflation is plus 1.6% every year, for the index. Don’t neglect that linkers pay in opposition to RPI, which is roughly 0.9% greater than CPI. An actual return of two.5% is explosive, as Kwasi Kwarteng will recall.
Till the interest-rate hikes in 2021, linkers had matched the FTSE 100, together with dividends, over the earlier 30 years. But since these hikes started, linkers have fallen by greater than 40%, whereas the FTSE is up 55%. By no means in historical past have we seen a niche so broad.
For the subsequent 25 years, I’m backing linkers. The only means is by way of the iShares Index-Linked Gilts Ucits ETF (LSE: INXG). For these with a robust disposition, take a look on the ultra-long dated points such because the 0.125% 2058, which locks in an actual return of greater than 2%. That may not sound like a lot, however you’re assured to double your cash. What’s extra, if and when inflation returns, the uplift can be vital, and your capital returns can be tax-free.

A couple of years in the past I used to be chatting with the psychologist Gerd Gigerenzer, who has printed analysis suggesting that straightforward guidelines of thumb usually carry out higher than intelligent concepts or refined fashions. We laughed about how tough it was to generate enterprise concepts from this revelation – usually probably the most priceless insights are easy and freely accessible, however costly advisors encourage pricey errors. For example, you’ll find Warren Buffett’s shareholder letters on the Berkshire Hathaway web site, whereas Merrill Lynch charged Royal Financial institution of Scotland tens of hundreds of thousands of kilos for recommendation supporting Fred Goodwin’s disastrous hostile bid for ABN Amro.
An funding prone to do effectively is the FTSE All-Share Index, a diversified benchmark consisting of slightly below 600 shares from the most important multinationals, similar to AstraZeneca, HSBC and Shell, all the way down to smaller, quirkier firms like Video games Workshop or Goodwin. The Barclays Fairness Gilt Examine reveals that equities are likely to compound at between 5% and seven% a yr over a long time.
Not each firm will generate that 5%-7% – however a diversified portfolio over the a long time is prone to. A world index such because the MSCI World index is an alternate, however whichever you select, choosing a low-cost tracker is vital. A 6% annual return, compounding every year, would quadruple your cash.
With a price of ten foundation factors every year charged on a £1,000 preliminary funding, an investor’s finish sum falls by roughly £100, from £4,300 to £4,200. An energetic fund supervisor who performs in keeping with the index, however expenses 1% yearly, would scale back the top sum by £900 to £3,400, taking a fifth of your funding. So, my choose for the subsequent 25 years is a low-cost FTSE All-Share Index tracker, and a subscription to MoneyWeek. Two choices are the iShares UK Fairness Index Fund and the Vanguard FTSE UK All Share Index Unit Belief.

There are many causes to be pessimistic about international traits, but a number of emerging-market economies needs to be a lot wealthier in 2050 so long as we keep away from the very worst geopolitical situations. Rising markets now comprise roughly half the world’s financial system, however solely 10% of the worth of most international inventory market indices, that are dominated by the US and the place the emerging-market half is generally China, Korea and Taiwan. So for a little bit of low-cost optimism, let’s choose Jardine Matheson (Singapore: J36). To keep away from confusion, observe that whereas the inventory technically has a main itemizing in London, virtually no person trades this. Jardine is a Hong Kong-based conglomerate relationship again to the early 1800s, with pursuits in automotive, building, engineering, hospitality, actual property, retail and extra. It operates principally in China and Hong Kong, Indonesia and the remainder of Southeast Asia.
The group is managed by the Keswicks, descendants of the Jardine household. I like family-run corporations that may take a protracted view, however they mustn’t stand nonetheless because the world adjustments. Jardine is simplifying its construction and intends to deal with being an funding holding firm reasonably than a household owner-operator, which implies extra outsiders operating its listed subsidiaries.
On 1 November 2000, Jardines closed at $5.75. On 31 October 2025, it closed at $58.75 – ten occasions greater, excluding dividends. A number of that is all the way down to a vastly profitable deal to rescue Indonesian conglomerate Astra in 2000. Can it discover a chance like that once more? More moderen offers means that it sees Vietnam as the very best prospect for an funding that may transfer the dial.
Apparent dangers vary from political shifts in China as to whether the ascendancy of electrical autos will undermine Astra’s dominance of automotive distribution in Indonesia. But Jardines trades on a worth/earnings (p/e) ratio of 11, a price-to-book worth ratio of 0.6 and a dividend yield of three.8%. It produces lots of money and has wonderful connections. You possibly can do lots worse.

In terms of fast-growing rising markets, the selection is between India and Vietnam. And Vietnam wins. It’s an Asian industrial dragon, with a younger, technically proficient workforce. It’s transferring up the value-added chain, particularly in know-how. GDP is increasing by greater than 6% a yr, more and more reliant on middle-income shoppers. The native inventory market is grime low-cost.
Vietnam has infinitely higher infrastructure than India, which is a crucial consideration for an export-orientated financial system. The emphasis on exports presents threats (within the type of tariffs) in addition to alternatives. I’d keep, barely controversially, that India’s socialist previous weighs extra closely on its present financial system than Vietnam’s dominant Communist Social gathering. Vietnam strikes me as totally capitalist, whereas India nonetheless boasts baffling examples of Fabian-style socialism.
India’s inhabitants is youthful than Vietnam’s, with a median age of 28 versus 33, however Vietnam’s workforce is best skilled and educated. Vietnam additionally options a way more strong feminine participation fee. In the meantime, owing to its dimension, Vietnam is best outfitted to keep away from the middle-income lure than India.
I’ve left the plain geopolitical challenge for final. India does boast a sturdy democracy, which is implausible, and Vietnam is self-evidently communist. Vietnam’s Communist Social gathering (CP) can be instinctively near the Chinese language CP. However if you’re the Trump administration, what do you suppose is extra vital – onshoring Vietnam’s low-cost labour industries (making earbuds for Apple and telephones for Samsung in Los Angeles, as an illustration) or having a detailed relationship with a regional energy (Vietnam) that’s not China? As enterprise capitalist Peter Thiel has famous, Vietnam serves as a non-expansionist hedge in opposition to China, one which lacks China’s imperial ambitions. Traders can acquire entry to the nation’s potential via the Vietnam Enterprise Investments Restricted (LSE: VEIL) funding belief.

The subsequent 25 years will see a rising demand for prescription drugs due to life-style components, rising life expectancy and the growing proportion of populations aged over 60. The proportion of over-60s in superior economies is anticipated to rise from 26%-30% in 2020 to 35%-45% in 2050, and the over-60s account for two-thirds of all medication. It will drive up the gross sales and revenue development of pharmaceutical firms.
Essentially the most severe illnesses for the over-60s are heart problems, persistent respiratory illness, most cancers, diabetes and dementia (primarily Alzheimer’s). Three of those – diabetes (circumstances have doubled since 2000), Alzheimer’s (a fourfold rise since 2000) and hypertensive coronary heart illness (greater than doubling since 2000) – rank because the fastest-growing main illnesses in rich international locations. We are able to add weight problems to those: the proportion of People labeled as overweight has risen from 15% in 1995 to 40% in 2024.
Traders ought to deal with massive firms making medication to deal with a number of of the key illnesses talked about above, with sturdy pipelines and substantial funding in analysis and improvement (R&D) to restock their pipelines. Two good examples are AstraZeneca (LSE: AZN) and Eli Lilly (NYSE: LLY). AstraZeneca specialises in oncology, cardiovascular, respiratory and uncommon illnesses. Lilly specialises in diabetes, weight problems, oncology, immunology and Alzheimer’s.
In 2024, AstraZeneca’s gross sales rose by 18% over 2023 and it invested 31.4% of gross sales in R&D. Lilly’s gross sales had been up 32% over 2023 and it invested 24.4% in R&D. AstraZeneca has 20 new molecular entities in its late-stage pipeline whereas Lilly has 25. Lilly is on a 2026 p/e of 26.7 and a ahead dividend yield of 0.75%; the respective figures for Astra are of 16.6 and 1.95%.

Smart (LSE: WISE) began with a easy enterprise mannequin. It was based in 2011 to supply shoppers a less expensive and quicker strategy to switch cash between currencies. Different suppliers used the outdated Swift system, which routes cash via middleman banks, including time and charges. Smart avoids this by not transferring cash throughout borders. As an alternative, Smart retains native financial institution accounts in quite a few international locations. When a person sends cash, Smart pays out from its native account within the vacation spot nation whereas receiving funds domestically of their house nation. This makes transfers quicker, cheaper and extra clear, as change charges and charges are proven up entrance. Whereas a Swift switch can take per week and price as much as 6%, Smart’s transfers are sometimes instantaneous and price a fraction of a %. Initially, prospects had been people like expatriates. This has developed – now the corporate serves small and medium-sized companies, saving them quite a lot of money and time.
Smart could possibly be a terrific funding for the subsequent 25 years. Its service is much forward of the competitors, which raises the query: what if others attempt to copy Smart? The reply is that Smart now provides its service to opponents. Greater than 85 banks now use Smart as an alternative of Swift, and this quantity is rising shortly. What started as a quick, low-cost service for expatriates is evolving into a world infrastructure that would underpin the worldwide funds system. If it succeeds, Smart may turn out to be one of many world’s most vital firms, and in doing so additionally one of the crucial priceless.
This text was first printed in MoneyWeek’s journal. Get pleasure from unique early entry to information, opinion and evaluation from our workforce of economic specialists with a MoneyWeek subscription.
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